Description

4-(Trifluoromethyl)Formanilide is a specialized aromatic amide derivative characterized by the presence of a formamide group and a trifluoromethyl substituent on the benzene ring. This compound serves as a crucial advanced pharmaceutical intermediate and a versatile building block in organic synthesis, valued for its ability to introduce the metabolically stable and lipophilic trifluoromethyl group into target molecules. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and agrochemicals.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and pesticides where the CF₃ group enhances biological activity and environmental stability.
• Material Science: Used in the research and production of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Organic Synthesis Reagent: Serves as a protected aniline derivative or a directing group in multi-step synthetic routes for complex heterocycles and fluorinated compounds.
• Chemical Research: Valuable reference standard and starting material in academic and industrial laboratories for studying fluorination effects and reaction mechanisms.

Basic Information

Product Name	4-(Trifluoromethyl)Formanilide
CAS No.	74702-40-2
Molecular Formula	C₈H₆F₃NO
Molecular Weight	189.14 g/mol
Synonyms	N-(4-(Trifluoromethyl)phenyl)formamide; 4-(Trifluoromethyl)benzenamine, N-formyl-; 4-Trifluoromethylformanilide; Formanilide, 4-(trifluoromethyl)-; p-(Trifluoromethyl)formanilide; 4-CF₃-Formanilide; N-Formyl-4-(trifluoromethyl)aniline
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Formanilide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.