Description

Insulin, Phe(A14)- is a specifically modified insulin analog where the alanine residue at position A14 of the A-chain is substituted with phenylalanine. This targeted structural alteration is of significant interest for advanced biochemical and pharmaceutical research, particularly in the study of insulin's structure-activity relationships, receptor binding kinetics, and metabolic stability. It serves as a critical intermediate and reference standard for scientists and manufacturers in the fields of peptide chemistry, diabetes research, and the development of novel therapeutic analogs.

Application

• Biochemical Research: Used as a key reference compound for studying insulin's folding, stability, and interaction with its receptor.
• Pharmaceutical Development: Serves as a crucial intermediate in the research and synthesis of novel insulin analogs with modified pharmacokinetic profiles.
• Structure-Activity Relationship (SAR) Studies: Essential for investigating how specific amino acid substitutions affect insulin's biological potency and duration of action.
• Metabolic Research: Employed in preclinical studies to understand the impact of structural modifications on glucose metabolism and signaling pathways.
• Quality Control & Analytical Standards: Functions as a high-purity certified reference material (CRM) for analytical method development and validation in QC laboratories.

Basic Information

Product Name	Insulin, Phe(A14)-
CAS No.	74622-64-3
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.5 g/mol (approx.)
Synonyms	Insulin (human) A14-Phe analog; [Phe(A14)]-Insulin; Insulin A-chain (A14-Phe) analog; Human Insulin Phe-A14; Insulin analog (A14Phe); [PheA14]-Insulin; Insulin, 14A-L-phenylalanine-
EINECS	Contact for details

Quality Control

Our Insulin, Phe(A14)- is manufactured under stringent conditions to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management systems to guarantee reliable and reproducible performance for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 8.0%
Biological Activity	Assessed by receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.