Description

N(Epsilon)-Acetimidoglucagon is a chemically modified derivative of the peptide hormone glucagon, where the ε-amino group of a specific lysine residue is acetimidylated. This modification is a critical tool in biochemical and pharmaceutical research, particularly for studying hormone-receptor interactions and developing stabilized peptide analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic disorder research, diabetes therapeutics development, and advanced peptide chemistry. The compound, identified by CAS No. 74619-75-3, offers a precise structural variant for probing biological function and stability.

Application

• Biochemical Research: Used as a key reference standard and molecular probe for studying the structure-activity relationship (SAR) of glucagon and its analogs.
• Pharmaceutical Development: Serves as an intermediate or a model compound in the R&D of novel, stabilized glucagon-based therapeutics for diabetes and hypoglycemia.
• Metabolic Studies: Employed in in vitro and ex vivo experiments to investigate glucagon signaling pathways, liver glucose metabolism, and hormone stability.
• Peptide Chemistry: Acts as a substrate for studying selective amino group modifications and developing conjugation strategies for peptide-drug conjugates.
• Quality Control & Analytics: Functions as a high-purity impurity standard or system suitability marker in the HPLC/MS analysis of glucagon and related peptide pharmaceuticals.

Basic Information

Item	Details
Product Name	N(Epsilon)-Acetimidoglucagon
CAS No.	74619-75-3
Molecular Formula	C153H225N43O49S
Molecular Weight	3484.7 g/mol (approx.)
Synonyms	Acetimidoglucagon; Glucagon, N6-(1-iminoethyl)-; N6-Acetimidoglucagon; Nε-Acetimidoglucagon; Monoacetimidoglucagon; Glucagon Acetimidate; [Lys(Acetimidyl)]-Glucagon; Glucagon derivative (acetimidylated)
EINECS	Contact for details

Quality Control

Our N(Epsilon)-Acetimidoglucagon is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, ensuring compliance with rigorous research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use and avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.