Description

H-Leu-Leu-Phe-Oh is a high-purity tripeptide derivative, specifically a leucine-leucine-phenylalanine sequence with a free carboxylic acid terminus. This compound serves as a critical building block and biochemical research tool for studying protease activity, peptide stability, and cellular signaling pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable, high-quality peptide intermediates for drug discovery and development.

Application

• Biochemical Research: Used as a standard substrate or inhibitor in enzymatic assays to study the kinetics and specificity of proteases like chymotrypsin or leucine aminopeptidases.
• Pharmaceutical Intermediates: Serves as a key synthetic building block in the development of novel peptide-based therapeutics and diagnostic agents.
• Cell Biology Studies: Employed in research to investigate peptide transport, metabolism, and receptor-ligand interactions within cellular systems.
• Proteomics & Peptide Library Synthesis: A valuable component for constructing focused peptide libraries used in high-throughput screening and biomarker discovery.
• Academic & Industrial R&D: Fundamental reagent for universities and contract research organizations (CROs) conducting basic and applied research in biochemistry and medicinal chemistry.

Basic Information

Product Name	H-Leu-Leu-Phe-Oh
CAS No.	74479-02-0
Molecular Formula	C₂₁H₃₃N₃O₄
Molecular Weight	391.51 g/mol
Synonyms	L-Leucyl-L-leucyl-L-phenylalanine; Leu-Leu-Phe; L-Leu-L-Leu-L-Phe-OH; H-LLF-OH; N-(L-Leucyl)-L-leucyl-L-phenylalanine; Tripeptide Leu-Leu-Phe; LLF; (2S)-2-[[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
EINECS	Contact for details

Quality Control

Our H-Leu-Leu-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.