Description

Argipressin, Phe(2)-(4-Azido)Phe(3)- is a synthetic, azido-functionalized analog of the neurohypophysial hormone arginine vasopressin (AVP). This modified peptide is a critical research tool in biochemistry and pharmacology, primarily used as a photoaffinity labeling agent to study vasopressin receptor structure, function, and binding sites. It is essential for scientists and R&D teams in pharmaceutical discovery, academic research, and biotechnology sectors investigating neuroendocrine pathways, receptor biology, and drug design.

Application

• Photoaffinity Labeling Studies: Acts as a covalent probe to identify and characterize vasopressin (V1a, V1b, V2) receptor proteins and their active sites upon UV irradiation.
• Biochemical Research: Used to investigate the structure-activity relationships (SAR) of vasopressin analogs and their interactions with target receptors.
• Drug Discovery & Development: A key reagent in the early-stage research for designing novel therapeutics targeting vasopressin pathways for conditions like diabetes insipidus, cardiovascular disorders, and social behaviors.
• Molecular Pharmacology: Employed in competitive binding assays and mechanistic studies to understand signal transduction and receptor dimerization.
• Proteomics & Target Identification: Facilitates the isolation and analysis of receptor complexes from cell membranes or tissue lysates for proteomic profiling.

Basic Information

Product Name	Argipressin, Phe(2)-(4-Azido)Phe(3)-
CAS No.	74274-75-2
Molecular Formula	C52H71N17O12S2
Molecular Weight	1174.36 g/mol
Synonyms	[Phe(2)-(p-N3Phe)]Arginine Vasopressin; [4-Azido-Phe2]AVP; [p-Azido-Phenylalanine2]Vasopressin; Photoaffinity AVP Analog; Azido-AVP; Argipressin azido analog; Vasopressin, 1-(3-mercaptopropanoic acid)-2-(4-azido-L-phenylalanine)-8-L-arginine-; (2-(4-Azidophenylalanine))arginine vasopressin
EINECS	Contact for details

Quality Control

Our Argipressin, Phe(2)-(4-Azido)Phe(3)- is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to stringent in-house quality standards and can provide material tailored to specific research-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic and strictly light-sensitive nature, the product should be handled under inert atmosphere or in a desiccator when aliquoting, and exposure to moisture and all light sources must be minimized to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Peptide Content)	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.