Description

β-Endorphin, Gln(8),Gly(31)-Gly-Gly-NH2 is a synthetic peptide analog of the endogenous neuropeptide β-endorphin, a key modulator of pain perception and stress response. This modified sequence offers enhanced stability and specific receptor interaction profiles for advanced research and development. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, analgesic drug discovery, and neuroendocrine studies.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of opioid receptor binding, signal transduction, and pain modulation pathways.
• Analgesic Drug Development: Serves as a lead compound or molecular tool for designing novel, non-addictive pain therapeutics with improved pharmacokinetic properties.
• In Vitro Bioassays: Employed in cell-based assays (e.g., cAMP inhibition, calcium flux) to screen for opioid receptor activity and agonist/antagonist effects.
• Neuroendocrine Studies: Investigates the role of endorphins in stress response, mood regulation, and immune system interactions.
• Biochemical Standard: Acts as a high-purity calibrant in analytical techniques such as HPLC and mass spectrometry for peptide quantification and identification.
• Preclinical Models: Administered in animal studies to evaluate behavioral effects, analgesic efficacy, and potential side-effect profiles of endorphin analogs.

Basic Information

Product Name	β-Endorphin, Gln(8),Gly(31)-Gly-Gly-NH2
CAS No.	74245-17-3
Molecular Formula	C158H251N43O46S
Molecular Weight	3466.0 g/mol (theoretical)
Synonyms	β-Endorphin (8-Gln, 31-Gly-Gly-NH2); [Gln8, Gly31-Gly-Gly-NH2]-β-Endorphin; β-Endorphin analog; H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Gln-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Gly-NH2; Opioid peptide analog; END(8-31) amide; β-LPH(61-91) analog
EINECS	Contact for details

Quality Control

Our β-Endorphin, Gln(8),Gly(31)-Gly-Gly-NH2 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results against stringent in-house specifications to ensure consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.