Description

H-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Oh is a high-purity synthetic peptide sequence, also known as a fragment of the amyloid beta (Aβ) protein, specifically Aβ(1-28). This compound is a critical research-grade biochemical tool, essential for studying protein aggregation mechanisms and neurodegenerative disease pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on Alzheimer's disease, amyloidosis, and peptide chemistry.

Application

• Neuroscience Research: As a key fragment of amyloid beta, it is used to study the aggregation kinetics, toxicity, and structural properties of Aβ peptides in models of Alzheimer's disease.
• Biochemical Assay Development: Serves as a standard or control in ELISA, Western blot, and other immunoassays designed to detect amyloid beta proteins.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and evaluate potential therapeutic compounds that inhibit Aβ aggregation or clear amyloid plaques.
• Peptide Structure-Activity Relationship (SAR) Studies: Provides a model system for investigating how specific amino acid sequences influence folding, stability, and biological activity.
• Academic & Clinical Research: Fundamental reagent for in vitro and in vivo studies exploring the etiology and progression of amyloid-related disorders.
• Biomaterial Science: Investigation of peptide self-assembly for creating novel nanomaterials or hydrogels.

Basic Information

Item	Detail
Product Name	H-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Oh
CAS No.	74221-77-5
Molecular Formula	C₁₂₀H₁₈₉N₃₅O₄₈
Molecular Weight	2848.0 g/mol (approximate)
Synonyms	Amyloid β-Protein (1-28); Aβ(1-28); Amyloid β-Peptide (1-28); β-Amyloid (1-28); Amyloid Beta (1-28) Fragment; Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys (Single-Letter Sequence: SDAV...); H-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
EINECS	Contact for details

Quality Control

Our Aβ(1-28) peptide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues, ensuring compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Single-Letter Sequence	SDAV... (Full sequence verified)
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.