Description

H-Leu-Phe-Nh2 Hcl is a high-purity dipeptide derivative, specifically the hydrochloride salt of the leucine-phenylalanine amide. This compound serves as a critical building block (protected dipeptide) in solid-phase peptide synthesis (SPPS) and other advanced organic syntheses. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality intermediates for developing novel therapeutic peptides and biochemical probes.

Application

• Pharmaceutical Intermediate: A key protected dipeptide unit for the synthesis of longer, complex peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in academic and industrial R&D for studying enzyme-substrate interactions, peptide structure-activity relationships (SAR), and metabolic pathways.
• Peptide Library Synthesis: An essential component in combinatorial chemistry for generating diverse peptide libraries used in drug discovery and high-throughput screening.
• Proteomics & Diagnostics: Can be utilized in the development of specialized reagents, standards, and probes for proteomic analysis and diagnostic assays.
• Cosmeceutical Peptides: Serves as a potential intermediate for synthesizing bioactive peptides used in advanced skincare and cosmetic formulations.

Basic Information

Product Name	H-Leu-Phe-Nh2 Hcl
CAS No.	74214-38-3
Molecular Formula	C15H24N3O2 • HCl
Molecular Weight	323.83 g/mol (Free base: 287.37 g/mol)
Synonyms	L-Leucyl-L-phenylalaninamide hydrochloride; H-Leu-Phe-NH2•HCl; Leu-Phe-amide HCl; N-(L-Leucyl)-L-phenylalaninamide hydrochloride; L-Leu-L-Phe-NH2 hydrochloride; Leucine-phenylalanine amide hydrochloride; (S)-2-((S)-2-Amino-4-methylpentanamido)-3-phenylpropanamide hydrochloride
EINECS	Contact for details

Quality Control

Our H-Leu-Phe-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.