Description

Des-Enkephalin-γ-Endorphin is a bioactive peptide fragment derived from the pro-opiomelanocortin (POMC) precursor. This compound is of significant interest in neuroscience and pharmaceutical research due to its potential role as an endogenous neuroleptic and its interactions with opioid and dopamine systems. It is primarily utilized by research institutions and pharmaceutical developers focused on neuropharmacology, psychiatry, and the study of endogenous behavior-modulating peptides.

Application

• Neuroscience Research: Used as a reference standard and investigative tool in studies of endogenous neuroleptics, opioid peptide pathways, and dopamine receptor modulation.
• Psychiatric Disorder Models: Employed in preclinical research to explore its effects in animal models related to schizophrenia, stress, and addiction.
• Biochemical Assay Development: Serves as a critical antigen or standard in the development of immunoassays (ELISA, RIA) for detecting related peptide fragments.
• Peptide Pharmacology: Investigated for its structure-activity relationships (SAR) to inform the design of novel neuroactive peptide therapeutics.
• Cell Signaling Studies: Applied in in vitro systems to study intracellular signaling cascades triggered by specific peptide-receptor interactions.

Basic Information

Product Name	Des-Enkephalin-γ-Endorphin
CAS No.	74174-40-6
Molecular Formula	C78H122N22O22S
Molecular Weight	1752.0 g/mol
Synonyms	DEγE; β-Endorphin (6-17); β-LPH (61-72); γ-Endorphin (Des-Tyr1); Des-Tyrosine1-γ-endorphin; DTγE; Human β-Lipotropin (61-72); Non-opioid γ-endorphin
EINECS	Contact for details

Quality Control

Our Des-Enkephalin-γ-Endorphin is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to GMP principles for peptide synthesis, and our quality systems support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.