Description

10H-Pyridazino[6,1-B]Quinazoline-2-Carboxylic Acid, 8-Chloro-10-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, where precise chemical building blocks are essential for innovation.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective applications.
• Organic Synthesis Building Block: Used in research and development for constructing complex polycyclic heterocyclic compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new pharmacophores.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for exploratory chemistry and methodology development.
• Process Chemistry Development: Acts as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	10H-Pyridazino[6,1-B]Quinazoline-2-Carboxylic Acid, 8-Chloro-10-Oxo-
CAS No.	74163-11-4
Molecular Formula	C14H6ClN3O3
Molecular Weight	299.67 g/mol
Synonyms	8-Chloro-10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acid; 8-Chloro-10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acid; 74163-11-4; 8-Chloro-10H-pyridazino[6,1-b]quinazoline-10-one-2-carboxylic acid; Pyridazino[6,1-b]quinazoline-2-carboxylic acid, 8-chloro-10-oxo-10H-; 8-Chloro-10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acid (ACI); 8-Chloro-10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acid (USAN)
EINECS	Contact for details

Quality Control

Our 10H-Pyridazino[6,1-B]Quinazoline-2-Carboxylic Acid, 8-Chloro-10-Oxo- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and can provide material suitable for research and development under quality systems aligned with cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.