Description

Enkephalin-Met, Acetaldehyde- is a chemically modified derivative of the endogenous opioid peptide [Met]-enkephalin, where an acetaldehyde moiety has been introduced. This modification is crucial for enhancing the peptide's metabolic stability and altering its receptor binding profile for advanced pharmacological research. It serves as a key intermediate and reference standard for neuroscientists and pharmaceutical developers working on novel analgesic and neuroprotective agents. The compound is essential for high-purity biochemical applications requiring precise molecular tools.

Application

• Neuroscience Research: Used as a critical tool for studying opioid receptor subtypes (μ, δ) and signal transduction pathways in the central nervous system.
• Drug Discovery & Development: Serves as a lead compound or intermediate for designing novel synthetic peptides with enhanced analgesic properties and improved pharmacokinetics.
• Biochemical Assays: Functions as a high-purity reference standard in competitive binding assays (e.g., ELISA, RIA) and activity studies to quantify biological activity.
• Metabolic Stability Studies: Employed to investigate the effects of chemical modifications on peptide degradation by enzymes like aminopeptidase N.
• Academic & Pharmaceutical R&D: A fundamental reagent for universities and biotech companies exploring pain management, addiction mechanisms, and neuropsychiatric disorders.

Basic Information

Product Name	Enkephalin-Met, Acetaldehyde-
CAS No.	74080-62-9
Molecular Formula	C29H39N5O8
Molecular Weight	585.65 g/mol
Synonyms	Acetaldehyde-Met-enkephalin; [Met5]-Enkephalin Acetaldehyde; N-Acetaldehyde-Met-enkephalin; Tyr-Gly-Gly-Phe-Met-CHO; H-Tyr-Gly-Gly-Phe-Met-CHO; Opioid Peptide Analog; (5S)-5-[(2S)-2-Acetamido-3-(4-hydroxyphenyl)propanamido]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propan-2-yl]-5-oxopentanamide (IUPAC-like); Met-Enkephalin Aldehyde
EINECS	Contact for details

Quality Control

Our Enkephalin-Met, Acetaldehyde- is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for structural confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting purity, identity, and other critical parameters. For specific project requirements, custom synthesis and purification to >95%, >98%, or >99% purity levels are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.