Description

2-Methylamino-4-n-Methylpiperazino-5-Methylthio-6-Chloropyrimidine Hydrochloride is a high-purity, complex heterocyclic building block with significant synthetic utility. This compound matters as a critical intermediate in the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile piperazine and chloropyrimidine moieties.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Fine Chemical Synthesis: Intermediate for creating more complex, functionalized pyrimidine derivatives with specific biological activities.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the life sciences industry.

Basic Information

Product Name	2-Methylamino-4-n-Methylpiperazino-5-Methylthio-6-Chloropyrimidine Hydrochloride
CAS No.	74039-21-7
Molecular Formula	C11H18ClN6S • HCl
Molecular Weight	339.73 g/mol (Free base: 303.82 g/mol)
Synonyms	2-(Methylamino)-4-(4-methylpiperazin-1-yl)-5-(methylthio)-6-chloropyrimidine Hydrochloride; 5-Methylthio-2-methylamino-4-(N-methylpiperazino)-6-chloropyrimidine Hydrochloride; 2-Methylamino-4-(4-methyl-1-piperazinyl)-5-(methylthio)-6-chloropyrimidine Hydrochloride; 6-Chloro-2-(methylamino)-4-(4-methylpiperazin-1-yl)-5-(methylsulfanyl)pyrimidine Hydrochloride; CAS 74039-21-7; N-Methyl-4-[(6-chloro-2-(methylamino)-5-(methylthio)pyrimidin-4-yl)]piperazine Hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Methylamino-4-n-Methylpiperazino-5-Methylthio-6-Chloropyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent in-house specifications suitable for research and development use. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.