Description

5-Chloro-2,4-difluoro-6-trifluoromethylpyrimidine is a high-value, multi-halogenated pyrimidine building block essential for advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and a trifluoromethyl group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS-targeted drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and electronic materials requiring specific halogenated aromatic systems.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring novel heterocyclic chemistry, cross-coupling reactions, and nucleophilic substitution pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services for complex molecules.

Basic Information

Product Name	5-Chloro-2,4-difluoro-6-trifluoromethylpyrimidine
CAS No.	74039-20-6
Molecular Formula	C5HClF5N2
Molecular Weight	216.52 g/mol
Synonyms	5-Chloro-2,4-difluoro-6-(trifluoromethyl)pyrimidine; 2,4-Difluoro-5-chloro-6-(trifluoromethyl)pyrimidine; 6-Trifluoromethyl-5-chloro-2,4-difluoropyrimidine; 74039-20-6; 5-Chloro-2,4-difluoro-6-trifluoromethyl-pyrimidine
EINECS	Contact for details

Quality Control

Our production of 5-Chloro-2,4-difluoro-6-trifluoromethylpyrimidine adheres to stringent in-process controls and final batch analysis to ensure consistent high purity and reliability. Each lot is characterized using advanced analytical techniques including GC, HPLC, NMR, and MS to confirm identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Purity (HPLC/GC)	≥ 99.0% (High Purity Grade)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.