Description

(+)-Carbocyclic Thromboxane A2 CAS NO 74034-57-4 is a stable, synthetic analog of the potent pro-thrombotic and vasoconstrictive eicosanoid, thromboxane A2 (TXA2). This compound serves as a crucial pharmacological tool and reference standard for studying thromboxane receptor (TP receptor) signaling pathways and related cardiovascular physiology. It is essential for researchers and developers in pharmaceutical R&D, contract research organizations (CROs), and academic institutions focused on thrombosis, hemostasis, and vascular biology.

Application

• Pharmacological Research: Used as a stable agonist for TP receptors to study receptor activation, downstream signaling cascades, and cellular responses in platelets and vascular smooth muscle cells.
• Drug Discovery & Development: Serves as a key reference compound and tool for screening and validating novel thromboxane receptor antagonists and synthase inhibitors for therapeutic applications.
• Biochemical Assays: Employed in in vitro assays to investigate platelet aggregation, vasoconstriction, and the role of thromboxane in inflammatory processes.
• Academic & Clinical Research: Utilized in studies exploring the pathophysiology of cardiovascular diseases, atherosclerosis, and thrombotic disorders.
• Analytical Reference Standard: Acts as a high-purity certified reference material (CRM) for analytical method development and validation in bioanalytical and pharmacokinetic studies.
• Quality Control: Used as an impurity marker or system suitability standard in the quality control of related pharmaceutical compounds.

Basic Information

Product Name	(+)-Carbocyclic Thromboxane A2
CAS No.	74034-57-4
Molecular Formula	C21H34O5
Molecular Weight	366.50 g/mol
Synonyms	Carbocyclic Thromboxane A2; (+)-CTxA2; 9,11-Epithio-11,12-methano-thromboxane A2; STA2; SQ 28,668; SQ-28668; (5Z,9α,11α,13E,15S)-9,11-Epithio-11,12-methano-15-hydroxy-thromboxa-5,13-dien-1-oic Acid
EINECS	Contact for details

Quality Control

Our (+)-Carbocyclic Thromboxane A2 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results. We support research and development with materials suitable for use as reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.