Description

Neurotensin (1-11) is a bioactive peptide fragment derived from the endogenous neuropeptide Neurotensin. This compound is a critical research tool for studying the physiological and pharmacological roles of neurotensin receptors (NTS1 and NTS2) in the central nervous system and gastrointestinal tract. It is essential for researchers and developers in the fields of neuroscience, endocrinology, and drug discovery, particularly for investigating receptor binding, signal transduction pathways, and potential therapeutic applications for neurological and metabolic disorders.

Application

• Neuroscience Research: Used as a standard or ligand in receptor binding assays and functional studies to elucidate the role of neurotensin in the brain.
• Drug Discovery & Development: Serves as a key reference compound for screening and developing novel neurotensin receptor agonists or antagonists for therapeutic use.
• Biochemical Assays: Employed in vitro to study intracellular signaling cascades, such as calcium mobilization and inositol phosphate turnover, activated by NTS1 receptor engagement.
• Pharmacological Studies: Utilized in animal models to investigate the effects of neurotensin on analgesia, hypothermia, locomotor activity, and dopamine modulation.
• Endocrinology & Metabolism Research: Applied in studies exploring the role of neurotensin in regulating gut motility, pancreatic secretion, and lipid metabolism.
• Academic & Institutional Research: A fundamental reagent for university and pharmaceutical R&D laboratories focusing on peptide biology and neuropeptide systems.

Basic Information

Product Name	Neurotensin (1-11)
CAS No.	74032-89-6
Molecular Formula	C₆₀H₉₃N₁₇O₁₃
Molecular Weight	1260.5 g/mol
Synonyms	Neurotensin 1-11; NT (1-11); pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr; L-Pyroglutamyl-L-leucyl-L-tyrosyl-L-glutamyl-L-asparaginyl-L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosine; Neurotensin fragment 1-11
EINECS	Contact for details

Quality Control

Our Neurotensin (1-11) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and MS for identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.