Description

Secretin, Asp(3)- is a synthetic analogue of the gastrointestinal peptide hormone secretin, where the third amino acid residue is aspartic acid. This high-purity peptide is critical for research and development in endocrinology and metabolic studies, serving as a precise biochemical tool. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on gastrointestinal physiology and hormone receptor interaction studies.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of pancreatic exocrine function, bicarbonate secretion, and gastric acid inhibition.
• Pharmacological Assays: Employed in in vitro and in vivo assays to investigate secretin receptor (SCTR) activation, signaling pathways, and drug discovery.
• Diagnostic Development: Serves as a key component in the development and calibration of diagnostic tests for pancreatic and gastrointestinal disorders.
• Biochemical Standard: Acts as a high-purity calibrant in analytical methods such as HPLC and mass spectrometry for peptide quantification.
• Structure-Activity Relationship (SAR) Studies: The specific Asp(3) modification makes it valuable for studying the impact of amino acid substitutions on peptide hormone activity and stability.

Basic Information

Item	Detail
Product Name	Secretin, Asp(3)-
CAS No.	73829-72-8
Molecular Formula	C130H220N44O41
Molecular Weight	3055.4 g/mol
Synonyms	Asp3-Secretin; [Asp3]-Secretin; Secretin (human) (Asp3); Secretin, Asp3-; H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 (Asp3 variant); Gastrointestinal peptide SCT analogue
EINECS	Contact for details

Quality Control

Our Secretin, Asp(3)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for peptide synthesis and can provide material traceable to analytical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Peptide Content)	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.