Description

(2S)-2-Amino-2-(fluoromethyl)-3-(3H-imidazol-4-yl)propanoic acid is a specialized, non-proteinogenic amino acid derivative that incorporates both a fluoromethyl group and an imidazole moiety. This unique structure makes it a valuable chiral building block and intermediate in advanced pharmaceutical research and development. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive compounds, particularly for applications in medicinal chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially those targeting neurological or metabolic pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and imidazole substitution on drug potency, selectivity, and metabolic stability.
• Peptidomimetic Synthesis: Serves as a fluorinated analog of histidine or other amino acids for creating modified peptides and peptidomimetics with enhanced properties.
• Biochemical Probe Development: Utilized in the design and synthesis of enzyme inhibitors or receptor ligands as tools for biochemical and pharmacological research.
• Isotope-Labeled Precursor: Acts as a starting material for the synthesis of carbon-13 or deuterium-labeled versions for use in metabolic and pharmacokinetic studies.

Basic Information

Product Name	(2S)-2-Amino-2-(fluoromethyl)-3-(3H-imidazol-4-yl)propanoic Acid
CAS No.	73804-75-8
Molecular Formula	C7H10FN3O2
Molecular Weight	187.17 g/mol
Synonyms	2-Amino-2-(fluoromethyl)-3-(1H-imidazol-4-yl)propanoic acid; (S)-2-Amino-2-(fluoromethyl)-3-(1H-imidazol-4-yl)propionic acid; L-2-Amino-2-(fluoromethyl)-3-(3H-imidazol-4-yl)propanoic acid; Fluoromethylhistidine; 4-(2-Amino-2-carboxy-3-fluoropropyl)imidazole; 73804-75-8; (S)-α-(Fluoromethyl)histidine
EINECS	Contact for details

Quality Control

Our production of (2S)-2-Amino-2-(fluoromethyl)-3-(3H-imidazol-4-yl)propanoic acid adheres to stringent quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.