Description

Adrenocorticotropic Hormone (Acth) (18-39), Human (Tfa) is a synthetic peptide fragment corresponding to the 18-39 sequence of the human adrenocorticotropic hormone, modified with a trifluoroacetyl (Tfa) group. This compound is a critical research tool for studying the structure-activity relationships of ACTH, particularly its binding and signaling mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on endocrinology, peptide therapeutics, and neurobiology. The CAS number for this compound is 73724-75-1.

Application

• Biomedical Research: Fundamental studies on ACTH receptor (melanocortin 2 receptor) binding, activation, and downstream signaling pathways.
• Drug Discovery: Serving as a reference standard or a lead compound in the development of novel peptide-based therapeutics targeting adrenal function and stress response.
• Endocrinology Studies: Investigating the role of specific ACTH domains in steroidogenesis and cortisol production in adrenal cortex models.
• Biochemical Assay Development: Use as a calibrated antigen in immunoassays (e.g., ELISA) or as a substrate in enzymatic studies related to peptide processing.
• Structure-Activity Relationship (SAR) Analysis: Mapping the bioactive regions of the full-length ACTH hormone to understand and optimize peptide function and stability.

Basic Information

Product Name	Adrenocorticotropic Hormone (Acth) (18-39), Human (Tfa)
CAS No.	73724-75-1
Molecular Formula	C₁₁₀H₁₆₈N₃₂O₃₃S • C₂HF₃O (TFA salt form)
Molecular Weight	~2485.7 g/mol (Free base)
Synonyms	ACTH (18-39), human; Adrenocorticotropic hormone fragment 18-39; hACTH (18-39); Corticotropin (18-39); ACTH (18-39) (human); Trifluoroacetyl-ACTH(18-39); TFA-ACTH(18-39); ACTH middle fragment
EINECS	Contact for details

Quality Control

Our Adrenocorticotropic Hormone (Acth) (18-39), Human (Tfa) is produced and controlled under a quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing specifications such as purity by HPLC, peptide content, and residual solvent levels. We support research and development with materials suitable for advanced biochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.