Description

Fmoc-Ala-Osu CAS NO 73724-40-0 is a highly reactive, protected amino acid derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the efficient, racemization-free incorporation of alanine into peptide chains under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an active ester (Osu), it serves as a crucial reagent for the efficient coupling of Fmoc-protected alanine to growing peptide chains on resin.
• Therapeutic Peptide Production: Used in the research-scale and commercial synthesis of peptide-based pharmaceuticals, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry: A fundamental component in libraries for drug discovery, allowing for the rapid assembly of diverse peptide sequences for screening.
• Bioconjugation: Facilitates the site-specific labeling of proteins, antibodies, or other biomolecules with alanine-containing tags or probes.
• Material Science: Employed in the synthesis of peptide-polymer hybrids and bio-inspired materials where controlled sequence is critical.
• Academic & Industrial Research: A standard reagent in laboratories focused on organic synthesis, medicinal chemistry, and chemical biology.

Basic Information

Product Name	Fmoc-Ala-Osu
CAS No.	73724-40-0
Molecular Formula	C22H20N2O6
Molecular Weight	408.41 g/mol
Synonyms	Fmoc-L-alanine N-hydroxysuccinimide ester; N-(9-Fluorenylmethoxycarbonyl)-L-alanine N-succinimidyl ester; Fmoc-L-Ala-OSu; Fmoc-Alanine-OSu; N-α-Fmoc-L-alanine N-hydroxysuccinimide ester; (9H-Fluoren-9-yl)methyl (2S)-2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethylcarbamate; Fmoc-Ala-ONSu; Fmoc-Ala-Osu ester
EINECS	Contact for details

Quality Control

Our Fmoc-Ala-Osu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing identity, purity (typically ≥98%), and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture will reduce its reactivity and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: -20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.