Description

Pyroglutaminyl-Seryl-Leucinamide CAS NO 73684-80-7 is a synthetic tripeptide derivative featuring a pyroglutamic acid (pGlu) N-terminus and a C-terminal amide. This specific structure makes it a valuable intermediate and reference standard in advanced biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences sector for studying peptide stability, metabolism, and receptor interactions.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of more complex peptide-based drug candidates and bioactive molecules.
• Biochemical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in peptide analysis (HPLC, MS).
• Neuroscience Studies: Investigated for its potential role in neurological pathways and as a model compound for studying peptide function in the central nervous system.
• Enzyme Substrate/Analog: Acts as a substrate or inhibitor for studying the activity of specific proteases and peptidases.
• Cosmeceutical Ingredient Development: Explored for potential applications in advanced skincare formulations targeting specific biological pathways.

Basic Information

Product Name	Pyroglutaminyl-Seryl-Leucinamide
CAS No.	73684-80-7
Molecular Formula	C17H29N5O6
Molecular Weight	399.44 g/mol
Synonyms	pGlu-Ser-Leu-NH2; Pyroglutamyl-Seryl-Leucinamide; 5-Oxo-L-prolyl-L-seryl-L-leucinamide; L-Pyroglutamyl-L-seryl-L-leucinamide; NSC 339243; Pyr-Ser-Leu-NH2; pESL-NH2
EINECS	Contact for details

Quality Control

Our Pyroglutaminyl-Seryl-Leucinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and specific optical rotation measurement. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every order to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.