Description

(3,5-Diiodo-Tyr5)-Lhrh is a chemically modified analog of the Luteinizing Hormone-Releasing Hormone (LHRH), where the tyrosine residue at position 5 is diiodinated. This specific modification is crucial for research into hormone-receptor interactions, stability studies, and the development of targeted diagnostic or therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies specializing in endocrinology and oncology.

Application

• Biochemical Research: Used as a key reagent in studying the structure-activity relationship (SAR) of LHRH and its receptor binding mechanisms.
• Pharmaceutical Development: Serves as a precursor or intermediate in the synthesis of novel peptide-based therapeutics targeting hormone-dependent conditions.
• Diagnostic Agent Research: The iodine atoms provide potential sites for radiolabeling (e.g., with I-125 or I-131) for use in imaging and diagnostic assays.
• Stability & Metabolism Studies: Employed to investigate the metabolic pathways and in-vivo stability of iodinated peptide analogs.
• Reference Standard: Acts as a high-purity analytical standard for quality control in peptide synthesis and characterization.

Basic Information

Product Name	(3,5-Diiodo-Tyr5)-Lhrh
CAS No.	73644-49-2
Molecular Formula	C64H84N18O13I2
Molecular Weight	1554.28 g/mol
Synonyms	(3,5-Diiodotyrosyl5)-Luteinizing Hormone-Releasing Hormone; LHRH (3,5-Diiodo-Tyr5) analog; pGlu-His-Trp-Ser-Tyr(3,5-I2)-Gly-Leu-Arg-Pro-Gly-NH2; Gonadorelin (3,5-Diiodo-Tyr5) derivative; Diiodo-LHRH; Luliberin (3,5-Diiodo-Tyr5) analog; 73644-49-2
EINECS	Contact for details

Quality Control

Our (3,5-Diiodo-Tyr5)-Lhrh is manufactured under strict quality protocols suitable for research and development applications. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.