Description

n-Acetyl-Met-Leu-Phe is a synthetic tripeptide derivative, widely recognized as a potent and specific formyl peptide receptor (FPR) agonist. This compound is a critical research tool for studying neutrophil chemotaxis, inflammation, and immune system signaling pathways. It is essential for pharmaceutical R&D, academic research, and the development of novel anti-inflammatory therapeutics.

Application

• Biomedical Research: A standard agonist for studying formyl peptide receptor (FPR1/FPR2) activation, calcium mobilization, and superoxide production in neutrophils and other immune cells.
• Inflammation & Immunology Studies: Used to model acute inflammatory responses and investigate mechanisms of chemotaxis and phagocytosis in vitro and in vivo.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening assays to identify novel FPR antagonists or modulators.
• Signal Transduction Research: Employed to elucidate downstream signaling cascades involving G-protein coupled receptors (GPCRs) and their role in immune regulation.
• Academic & Pharmaceutical Development: Used in universities, research institutes, and biotech companies for fundamental research and preclinical development of anti-inflammatory agents.

Basic Information

Product Name	n-Acetyl-Met-Leu-Phe
CAS No.	73572-34-6
Molecular Formula	C23H34N4O5S
Molecular Weight	478.60 g/mol
Synonyms	N-Acetyl-Met-Leu-Phe; N-Acetyl-MLF; Ac-Met-Leu-Phe; Ac-MLF; fMLF; N-Formyl-Met-Leu-Phe (common functional analog); N-Acetyl-methionyl-leucyl-phenylalanine; Chemotactic Peptide N-Acetyl-MLF
EINECS	Contact for details

Quality Control

Our n-Acetyl-Met-Leu-Phe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and chiral purity checks. A detailed Certificate of Analysis (COA) providing batch-specific data is available for all research and commercial grades.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.