Description

α-Methyl-L-Valine Hcl is a high-purity, non-proteinogenic amino acid derivative used as a critical building block in advanced organic synthesis. Its modified valine structure makes it a valuable chiral intermediate for creating complex molecules with specific stereochemical requirements. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, especially protease inhibitors and other targeted therapies.
• Peptide Synthesis: Used to incorporate modified valine residues into custom peptides, enhancing their metabolic stability, bioavailability, or binding affinity.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway investigations due to its structural similarity to L-valine.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective chemical reactions to induce desired chirality in final products.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel chiral ligands and organocatalysts for industrial catalytic processes.

Basic Information

Product Name	α-Methyl-L-Valine Hcl
CAS No.	73473-42-4
Molecular Formula	C6H14ClNO2
Molecular Weight	167.63 g/mol
Synonyms	(2S)-2-Amino-2-methyl-3-methylbutanoic acid hydrochloride; L-α-Methylvaline hydrochloride; (S)-2-Amino-2-methyl-3-methylbutyric acid hydrochloride; H-α-Me-Val-OH·HCl; (S)-2-Amino-3-methyl-2-methylbutanoic acid hydrochloride; 2-Amino-2-methyl-3-methylbutanoic acid hydrochloride (L-form); α-Methyl-L-valine monohydrochloride
EINECS	Contact for details

Quality Control

Our α-Methyl-L-Valine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.