Description

Insulin, 4-Azidobenzoyl(B29)- CAS NO 73468-14-1 is a chemically modified insulin derivative where an azidobenzoyl group is specifically conjugated to the B29 lysine residue. This modification is critical for creating photoactivatable or affinity probes used in advanced biochemical research and diagnostic development. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for studying insulin receptor interactions, metabolic pathways, and for the development of novel therapeutic and diagnostic platforms.

Application

• Photoaffinity Labeling: Acts as a crucial probe for mapping insulin binding sites on its receptor and other interacting proteins through UV-induced cross-linking.
• Bioconjugation & Probe Development: Serves as a key intermediate for synthesizing fluorescent, radioactive, or biotinylated insulin conjugates for various detection and imaging applications.
• Metabolic Research: Used in fundamental studies to investigate insulin signaling pathways, glucose metabolism, and related disorders.
• Drug Discovery: Employed in high-throughput screening assays to identify and characterize new compounds that modulate insulin receptor activity.
• Diagnostic Reagent Manufacturing: Incorporated into the development of advanced immunoassays and biosensors for the precise measurement of insulin and anti-insulin antibodies.
• Structural Biology: Aids in structural studies using techniques like cryo-EM or X-ray crystallography to understand insulin-receptor complex formation.

Basic Information

Product Name	Insulin, 4-Azidobenzoyl(B29)- CAS NO 73468-14-1
CAS No.	73468-14-1
Molecular Formula	C257H387N65O78S6
Molecular Weight	~5808.5 g/mol
Synonyms	4-Azidobenzoyl-Insulin; NεB29-4-Azidobenzoyl-Insulin; Insulin B29-azidobenzoate; Photoactivatable Insulin; Insulin, 4-azidobenzoyl- (B29-); Insulin azidobenzoate derivative; Azido-Benzoyl Insulin; Insulin-ABz
EINECS	Contact for details

Quality Control

Our Insulin, 4-Azidobenzoyl(B29)- CAS NO 73468-14-1 is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Assessed by receptor binding assay
Solubility	Soluble in DMSO, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.