Description

3,5-Difluoro-L-Tyrosine is a fluorinated derivative of the essential amino acid L-tyrosine, distinguished by fluorine atoms at the 3 and 5 positions of the aromatic ring. This structural modification is critical for its role as a key building block in the synthesis of novel peptides and radiopharmaceuticals, where it serves as a probe for positron emission tomography (PET) imaging. It is primarily utilized by pharmaceutical R&D teams, radiochemistry laboratories, and advanced material scientists developing targeted diagnostics and bioactive compounds.

Application

• Radiopharmaceutical Precursor: A crucial intermediate for synthesizing fluorine-18 (18F) labeled PET tracers for oncology and neurology research.
• Peptide Synthesis: Used in solid-phase peptide synthesis (SPPS) to incorporate fluorinated tyrosine residues, altering peptide stability, bioavailability, and receptor binding properties.
• Biochemical Research: Serves as a tool compound in enzyme inhibition studies and metabolic pathway analysis due to its tyrosine analog structure.
• Proteomics & Labeling: Employed in the development of affinity tags and chemical probes for protein labeling and pull-down assays.
• Medicinal Chemistry: A valuable scaffold for designing novel drug candidates targeting tyrosine kinase pathways and other biological processes.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3,5-Difluoro-L-Tyrosine
CAS No.	73246-30-7
Molecular Formula	C9H9F2NO3
Molecular Weight	217.17 g/mol
Synonyms	L-Tyrosine, 3,5-difluoro-; (2S)-2-Amino-3-(3,5-difluoro-4-hydroxyphenyl)propanoic acid; 3,5-Difluorotyrosine; 3,5-Difluoro-DL-tyrosine (related to racemic mixture); 3,5-Difluorotyrosine, L-; F2Tyr; DFY; 3,5-F2-Tyr
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-L-Tyrosine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and MS. We provide Certificates of Analysis (COA) with each shipment, detailing all specified parameters to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.