Description

Leu-Leu-Leu Amide is a synthetic tripeptide derivative, specifically the amide of the L-Leucyl-L-leucyl-L-leucine sequence. This compound serves as a crucial building block and biochemical tool in advanced research and development. It is primarily utilized by professionals in the pharmaceutical, biotechnology, and life science sectors for applications such as peptide synthesis, proteomics research, and as a reference standard.

Application

• Peptide Synthesis Intermediate: A key protected fragment for the solid-phase or solution-phase synthesis of longer, more complex peptides and peptidomimetics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving proteases like leucine aminopeptidases, to investigate enzyme kinetics and mechanisms.
• Pharmaceutical Development: Acts as a precursor or model compound in the discovery and development of novel therapeutic agents targeting various diseases.
• Proteomics & Cell Biology: Employed in studies of protein-protein interactions, signal transduction pathways, and cellular processes related to leucine metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control (QC) and method validation in analytical laboratories using HPLC, LC-MS, or NMR.

Basic Information

Product Name	Leu-Leu-Leu Amide
CAS No.	73237-77-1
Molecular Formula	C₁₈H₃₅N₅O₃
Molecular Weight	369.50 g/mol
Synonyms	L-Leucyl-L-leucyl-L-leucinamide; H-Leu-Leu-Leu-NH₂; Leu-Leu-Leu-NH₂; Trileucinamide; N-(L-Leucyl)-L-leucyl-L-leucinamide; L-Leu-L-Leu-L-Leu-NH2; LL-L Amide; Leucine Tripeptide Amide
EINECS	Contact for details

Quality Control

Our Leu-Leu-Leu Amide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from techniques including HPLC, NMR, and MS. Our quality commitment supports applications requiring high-purity biochemicals for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Total)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.