Description

H-Leu-Leu-Nh2 Hcl is a high-purity dipeptide derivative, specifically the hydrochloride salt of the leucine-leucine amide. This compound serves as a critical building block (protected amino acid) and pharmacological research intermediate in advanced organic synthesis. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and peptide chemistry sectors, where precise molecular control is paramount for developing novel therapeutics and biochemical tools.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a key substrate or inhibitor in enzymatic studies and proteomics research.
• Peptide Synthesis: Acts as a protected dipeptide unit in solid-phase and solution-phase peptide synthesis (SPPS).
• Protease/Enzyme Studies: Utilized to investigate the specificity and mechanism of proteolytic enzymes like leucine aminopeptidases.
• Cell Culture & Microbiology: May be employed as a specialized nutrient component in advanced cell culture media.
• Chemical Biology Tool: Functions as a molecular probe for studying protein-protein interactions and signal transduction pathways.

Basic Information

Product Name	H-Leu-Leu-Nh2 Hcl
CAS No.	73237-75-9
Molecular Formula	C₁₂H₂₅N₃O₂ • HCl
Molecular Weight	279.81 g/mol (Free base: 243.35 g/mol)
Synonyms	L-Leucyl-L-leucinamide hydrochloride; Leu-Leu-NH2 • HCl; H-Leu-Leu-NH2 • HCl; L-Leu-L-Leu-NH2 hydrochloride; N-(L-Leucyl)-L-leucinamide monohydrochloride; 2-[(2-Amino-4-methylpentanoyl)amino]-4-methylpentanamide hydrochloride; Leucine-leucine amide hydrochloride; Dipeptide amide Leu-Leu-NH2 HCl
EINECS	Contact for details

Quality Control

Our H-Leu-Leu-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.