Description

p-(Trifluoromethyl)Phenol is a high-purity fluorinated aromatic compound, also known as 4-(Trifluoromethyl)phenol. This specialty chemical is a critical building block in advanced organic synthesis, valued for the unique electronic and steric properties imparted by the trifluoromethyl group. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in molecules requiring enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the CF₃ group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of fluorinated components for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter thermal stability, chemical resistance, and surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, etherification, and as a protecting group in complex multi-step synthetic routes.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	p-(Trifluoromethyl)Phenol
CAS No.	73073-69-5
Molecular Formula	C₇H₅F₃O
Molecular Weight	162.11 g/mol
Synonyms	4-(Trifluoromethyl)phenol; 4-Hydroxybenzotrifluoride; α,α,α-Trifluoro-p-cresol; 4-Trifluoromethylphenol; p-Hydroxybenzotrifluoride; Phenol, 4-(trifluoromethyl)-; NSC 2215; F3CC6H4OH
EINECS	Contact for details

Quality Control

Our p-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored in amber glass or opaque containers. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.