Description

(Pglu16)-Vasoactive Intestinal Peptide Fragment 16-28 is a synthetic peptide fragment derived from the biologically active Vasoactive Intestinal Peptide (VIP). This compound is a critical research tool for studying neuroendocrine signaling, immune modulation, and smooth muscle relaxation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on peptide-based therapeutics and advanced biochemical studies. The product is supplied as a high-purity, lyophilized powder to ensure consistent performance in sensitive applications.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of VIP receptor (VPAC1/VPAC2) binding, signaling pathways, and physiological functions.
• Drug Discovery & Development: Serves as a key intermediate or pharmacophore model for designing novel peptide therapeutics targeting inflammatory, neurological, and cardiovascular diseases.
• In Vitro Diagnostics: Employed in the development and calibration of immunoassays (ELISA, RIA) for detecting VIP-related biomarkers.
• Cell Culture & Physiology Studies: Applied in cell-based assays to investigate its effects on cAMP production, vasodilation, and immune cell regulation.
• Neuroscience Research: Utilized to explore the role of VIP fragments in neuronal survival, circadian rhythms, and neuroprotection.

Basic Information

Product Name	(Pglu16)-Vasoactive Intestinal Peptide Fragment 16-28
CAS No.	73073-47-9
Molecular Formula	C76H112N20O23S
Molecular Weight	1721.9 g/mol
Synonyms	VIP (16-28), pGlu-VIP(16-28); VIP Fragment 16-28; Pyr-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 (cyclic notation); Vasoactive Intestinal Polypeptide (16-28); L-Pyroglutamyl-L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-asparaginamide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of (Pglu16)-Vasoactive Intestinal Peptide Fragment 16-28 undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For cGMP-grade material or custom purity requirements, please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ± 10% of theoretical
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.