Description

Thiofentanil Oxalate CAS NO 73005-06-8 is a potent synthetic opioid analgesic compound, primarily utilized in advanced pharmacological research. This high-purity chemical is critical for studying opioid receptor mechanisms, analgesic pathways, and structure-activity relationships. It serves as an essential reference standard and intermediate for pharmaceutical R&D teams, toxicology laboratories, and forensic science institutions focused on developing new therapeutic agents or analytical methods.

Application

• Pharmacological Research: Used as a potent reference compound for in vitro and in vivo studies of opioid receptor (μ-opioid receptor) binding affinity, efficacy, and signal transduction pathways.
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for the calibration of analytical equipment (HPLC, GC-MS, LC-MS) in forensic toxicology and pharmaceutical quality control laboratories.
• Structure-Activity Relationship (SAR) Studies: A key intermediate for medicinal chemists exploring the modification of fentanyl-related structures to understand and optimize potency, selectivity, and metabolic stability.
• Biochemical Assay Development: Employed in the development and validation of competitive binding assays and other biochemical screens to identify novel opioid ligands or antagonists.
• Forensic Analysis: Used as an analytical standard for the precise identification and quantification of novel synthetic opioids in forensic casework and substance monitoring programs.
• Controlled Substance Analog Research: Provides a critical material for authorized research into the properties, detection, and effects of synthetic opioid analogs.

Basic Information

Product Name	Thiofentanil Oxalate
CAS No.	73005-06-8
Molecular Formula	C₂₃H₃₂N₂O₅S
Molecular Weight	448.58 g/mol
Synonyms	Thiofentanyl Oxalate; 4-(Methoxycarbonyl)-4-(N-phenylpropanamido)-1-(2-thienylmethyl)piperidine Oxalate; 1-(2-Thienylmethyl)-4-(N-phenylpropionamido)-4-piperidinecarboxylic Acid Methyl Ester Oxalate; 4-Piperidinecarboxylic acid, 1-[(2-thienyl)methyl]-4-[(1-oxopropyl)phenylamino]-, methyl ester, (2R,3R)-2,3-dihydroxybutanedioate (1:1); Thiofentanil Hydrogen Oxalate
EINECS	Contact for details

Quality Control

Our Thiofentanil Oxalate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, identity confirmation via IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.