Description

3',4'-Dideoxyamikacin is a semi-synthetic derivative of the broad-spectrum aminoglycoside antibiotic amikacin. This compound is of significant interest in pharmaceutical research and development for its potential to overcome bacterial resistance mechanisms. It serves as a key intermediate and reference standard for scientists in the fields of medicinal chemistry and antibiotic discovery. The product is identified by CAS No. 72908-95-3.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel aminoglycoside antibiotics and derivatives.
• Antibiotic Research: Used as a reference compound in structure-activity relationship (SAR) studies to understand and improve antibacterial efficacy.
• Microbiological Studies: Employed in laboratory research to investigate bacterial resistance pathways and mechanisms of action.
• Analytical Standard: Serves as a high-purity standard for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.
• Biochemical Reagent: Utilized in enzymatic and molecular biology studies related to protein synthesis inhibition.

Basic Information

Product Name	3',4'-Dideoxyamikacin
CAS No.	72908-95-3
Molecular Formula	C22H43N5O12
Molecular Weight	569.61 g/mol
Synonyms	3',4'-Dideoxyamikacin; 1-N-[(S)-4-Amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin A; 3',4'-Dideoxy-1-N-[(S)-4-amino-2-hydroxybutyryl]kanamycin A; Amikacin 3',4'-dideoxy derivative; Antibiotic BB-K 311; (2S)-4-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
EINECS	Contact for details

Quality Control

Our 3',4'-Dideoxyamikacin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.