Description

7-Hydroxydigoxin is a key cardiac glycoside derivative and a significant metabolite of digoxin. This compound is of paramount importance in pharmaceutical research and development, particularly for studying the metabolism, pharmacokinetics, and structure-activity relationships of digitalis drugs. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling precise analytical work and the development of new therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of digoxin and its metabolites in biological samples via HPLC, LC-MS, or GC-MS.
• Metabolite Research: Essential for studying the metabolic pathways, bioavailability, and excretion profiles of digoxin in preclinical and clinical research.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a high-purity building block in the synthetic pathways for novel cardiac therapeutics.
• Biochemical Research: Employed in studies investigating the mechanism of action of cardiac glycosides on sodium-potassium ATPase pumps.
• Quality Control & Assurance: Critical for pharmaceutical manufacturers to validate analytical methods and ensure the purity and consistency of digoxin-based drug products.
• Toxicology Studies: Used as a standard in forensic and clinical toxicology to assess digoxin levels and potential overdose scenarios.

Basic Information

Product Name	7-Hydroxydigoxin
CAS No.	72908-79-3
Molecular Formula	C₄₁H₆₄O₁₄
Molecular Weight	780.94 g/mol
Synonyms	7β-Hydroxydigoxin; Digoxin, 7-hydroxy-; 3β,12β,14-Trihydroxy-5β-card-20(22)-enolide 3-(2,6-dideoxy-4-O-β-D-glucopyranosyl-β-D-ribo-hexopyranoside); 7-Hydroxy-12β,14-dihydroxydigoxin; 7-OH-Digoxin
EINECS	Contact for details

Quality Control

Our 7-Hydroxydigoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.