Description

Suc-Ala-Ala-Pro-Ile-Pna is a chromogenic peptide substrate designed for the specific detection and quantification of proteolytic enzyme activity. This compound matters for researchers and quality control professionals who require precise, reliable, and reproducible assays for enzymes like elastase and related serine proteases. It is primarily needed by the pharmaceutical, biotechnology, and academic research sectors for drug discovery, biochemical research, and enzymatic process monitoring.

Application

• Enzymatic Assay Substrate: Primary substrate for the spectrophotometric determination of human leukocyte elastase (HLE) and pancreatic elastase activity.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel elastase inhibitors for therapeutic development.
• Biochemical Research: A critical tool for studying protease kinetics, specificity, and inhibition mechanisms in vitro.
• Diagnostic Reagent Component: Employed in the development of diagnostic kits for conditions involving dysregulated elastase activity.
• Quality Control in Bioprocessing: Monitors protease activity during the production and purification of biopharmaceuticals.
• Inflammation & Disease Modeling: Facilitates research into inflammatory diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, and rheumatoid arthritis.

Basic Information

Product Name	Suc-Ala-Ala-Pro-Ile-Pna
CAS No.	72682-77-0
Molecular Formula	C29H41N7O8
Molecular Weight	615.68 g/mol
Synonyms	N-Succinyl-Ala-Ala-Pro-Ile-p-nitroanilide; Suc-AAPF-pNA; Suc-AAPF-pNA; Suc-(Ala)2-Pro-Ile-pNA; Elastase Substrate IV; N-Succinyl-Alanyl-Alanyl-Prolyl-Isoleucyl-p-Nitroanilide; Suc-Ala-Ala-Pro-Ile-p-Nitroanilide; AAPF-pNA
EINECS	Contact for details

Quality Control

Our Suc-Ala-Ala-Pro-Ile-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive enzymatic assays. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and performance reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Specific Optical Rotation	Contact for details
Extinction Coefficient	~ 10,000 M-1cm-1 at 410 nm (after cleavage)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.