Description

5-Chloro-2,4-difluoro-6-methylpyrimidine is a high-purity, multi-functional halogenated pyrimidine building block essential for advanced chemical synthesis. This compound is valued for its unique reactivity profile, enabling the precise introduction of chlorine and fluorine substituents into complex molecular architectures. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro groups enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring specific halogenated heterocycles.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and in process chemistry for route scouting and optimization.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up manufacturing under cGMP or ISO standards.

Basic Information

Product Name	5-Chloro-2,4-difluoro-6-methylpyrimidine
CAS No.	72630-78-5
Molecular Formula	C5H3ClF2N2
Molecular Weight	164.54 g/mol
Synonyms	5-Chloro-2,4-difluoro-6-methylpyrimidine; 2,4-Difluoro-5-chloro-6-methylpyrimidine; 6-Methyl-5-chloro-2,4-difluoropyrimidine; 5-Chloro-2,4-difluoro-6-methyl-1,3-diazine; Pyrimidine, 5-chloro-2,4-difluoro-6-methyl-; CAS 72630-78-5
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4-difluoro-6-methylpyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high standards, including cGMP intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.