Description

Somatostatin, De-Asn(5)-Trp(8)-Ser(13)- is a synthetic analogue of the endogenous peptide hormone somatostatin, designed with specific amino acid modifications to enhance its stability and receptor binding profile. This engineered compound is critical for advanced biochemical research and pharmaceutical development, offering a valuable tool for studying hormonal regulation and metabolic pathways. It is primarily utilized by research institutions, biotechnology companies, and pharmaceutical developers focused on endocrinology, oncology, and metabolic disease research.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of somatostatin receptor (SSTR) signaling, function, and inhibition mechanisms.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutic agents targeting neuroendocrine tumors and acromegaly.
• Endocrinology Studies: Applied in in vitro and in vivo models to investigate the regulation of growth hormone, insulin, and glucagon secretion.
• Receptor Binding Assays: Essential for competitive binding studies and the characterization of new SSTR ligands due to its defined structure and activity.
• Metabolic Pathway Analysis: Utilized in research exploring the role of somatostatin in glucose homeostasis and gastrointestinal function.

Basic Information

Product Name	Somatostatin, De-Asn(5)-Trp(8)-Ser(13)-
CAS No.	72541-25-4
Molecular Formula	C72H104N18O19S2
Molecular Weight	~1638.9 g/mol
Synonyms	Des-Asn5-Trp8-Ser13-Somatostatin; [Des-Asn5, D-Trp8, Ser13]-Somatostatin; Somatostatin (3-14) fragment, [D-Trp8]-; Cyclo(3-14)[Cys3-Cys14]-[D-Trp8, Ser13]somatostatin; SRIF analogue; SSTR ligand; BIM-23014 (research code)
EINECS	Contact for details

Quality Control

Our Somatostatin, De-Asn(5)-Trp(8)-Ser(13)- is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances. We adhere to relevant guidelines for peptide synthesis, and custom synthesis to specific pharmacopeial standards (e.g., USP reference standards grade) can be discussed.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% on anhydrous basis
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%; Any single unknown impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.