Description

Lodiperone is a high-purity pharmaceutical intermediate and research chemical with significant importance in modern medicinal chemistry. Its primary value lies in its role as a key building block for the synthesis of novel therapeutic agents, particularly within the central nervous system (CNS) domain. This compound is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new drug candidates and advanced pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of advanced active pharmaceutical ingredients (APIs) and novel drug molecules.
• Neurological Research: Used as a reference standard and building block in neuroscience research for studying receptor interactions and developing CNS-targeted therapies.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities with potential psychotropic activity.
• Process Development: Employed in the optimization and scale-up of synthetic routes for complex organic molecules within GMP and non-GMP environments.
• Analytical Reference Standard: Utilized in quality control laboratories for method development, validation, and as a certified reference material (CRM) for HPLC, GC, and spectroscopic analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and pilot-scale production.

Basic Information

Product Name	Lodiperone
CAS No.	72444-63-4
Molecular Formula	C23H28FN3O2
Molecular Weight	397.49 g/mol
Synonyms	Lodiperone; 1-[4-[4-(4-Fluorophenyl)-4-oxobutyl]-1-piperazinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[4-[4-(4-Fluorophenyl)-4-oxobutyl]piperazin-1-yl]-1,3-dihydro-2H-benzimidazol-2-one; 1-(4-(4-(4-Fluorophenyl)-4-oxobutyl)piperazin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one; CRM-197; Lodiperon; Lodiperonum
EINECS	Contact for details

Quality Control

Our Lodiperone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification (IR, NMR), assay (HPLC), and impurity profiling to meet stringent in-house specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates, ensuring suitability for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.