Description

Meosuc-Ala-Ala-Pro-Val-Amc is a specialized fluorogenic peptide substrate designed for sensitive enzymatic activity assays. This compound is critical for researchers and quality control laboratories requiring precise measurement of protease activity, particularly elastase. It is primarily utilized in pharmaceutical R&D, biochemical research, and diagnostic kit development where high-purity, reliable substrates are essential for accurate kinetic studies and inhibitor screening.

Application

• Enzymatic Assay Substrate: A fluorogenic substrate for the continuous, sensitive detection and quantification of human leukocyte elastase (HLE) and related serine proteases.
• Pharmaceutical Research: Used in high-throughput screening (HTS) campaigns to identify and characterize novel elastase inhibitors for therapeutic development in conditions like chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
• Biochemical Research: Essential for kinetic studies, enzyme characterization, and mechanistic investigations of protease function and regulation in academic and industrial laboratories.
• Diagnostic Development: Serves as a key component in the formulation of diagnostic kits and reagents for measuring elastase activity in clinical and research samples.
• Quality Control (QC): Employed in biopharmaceutical manufacturing QC to monitor the activity and consistency of enzyme-based products or processes.

Basic Information

Product Name	Meosuc-Ala-Ala-Pro-Val-Amc
CAS No.	72252-90-5
Molecular Formula	C24H35N5O8
Molecular Weight	521.57 g/mol
Synonyms	N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-Amino-4-methylcoumarin; Methoxysuccinyl-Ala-Ala-Pro-Val-AMC; MeOSuc-AAPV-AMC; Elastase Substrate IV; HLE Substrate; Suc(OMe)-Ala-Ala-Pro-Val-AMC; AAPV-AMC; 7-Amino-4-methylcoumarin conjugate of MeOSuc-AAPV
EINECS	Contact for details

Quality Control

Our Meosuc-Ala-Ala-Pro-Val-Amc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high performance in sensitive assays. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and functional activity testing. A detailed Certificate of Analysis (COA) providing purity, assay, and impurity profiles is supplied with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Functional)	≥ 98.0% (enzymatic activity)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.