Description

Mastoparan X CAS NO 72093-22-2 is a potent, amphiphilic peptide toxin derived from wasp venom, known for its ability to activate G-proteins and stimulate phospholipase C. This makes it a critical research tool for studying intracellular signal transduction pathways, particularly those involving heterotrimeric G-proteins and mast cell degranulation. It is primarily utilized by researchers and scientists in the fields of pharmacology, cell biology, and neuroscience for investigating receptor-independent G-protein activation, calcium signaling, and exocytosis.

Application

• Biochemical Research: A fundamental tool for studying G-protein coupled receptor (GPCR) signaling cascades and phospholipase C (PLC) activation in vitro.
• Cell Biology Studies: Used to investigate mast cell and granulocyte degranulation, histamine release, and calcium ion (Ca²⁺) mobilization in cellular models.
• Neuroscience Research: Employed to explore the role of G-proteins in neuronal signaling, neurotransmitter release, and synaptic plasticity mechanisms.
• Pharmacology Screening: Serves as a positive control or reference compound in assays designed to identify novel G-protein inhibitors or modulators.
• Membrane Interaction Studies: Utilized to examine the interactions of amphiphilic peptides with lipid bilayers and their pore-forming activities.
• Drug Discovery: Provides insights into pathways relevant to inflammatory and allergic responses, aiding in target validation.

Basic Information

Product Name	Mastoparan X
CAS No.	72093-22-2
Molecular Formula	C71H111N21O20
Molecular Weight	1550.8 g/mol
Synonyms	Mastoparan X (Vespula lewisii); Mastoparan-X; IN-WI-1; Mastoparan 7; Ile-Asn-Leu-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2; H-INWKGIAAMAKKIL-NH2; Vespula lewisii mastoparan.
EINECS	Contact for details

Quality Control

Our Mastoparan X is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.