Description

1,7-Dihydro-2-(Dimethylamino)-6H-Purin-6-One Bis(Trimethylsilyl) is a key silylated purine derivative, serving as a versatile and protected intermediate in advanced organic synthesis. Its primary value lies in enabling efficient, high-yield reactions for constructing complex heterocyclic systems, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for nucleoside and nucleotide analog synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel purine-based drug candidates, including antiviral and anticancer agents.
• Nucleoside/Nucleotide Chemistry: Used in the preparation of silyl-protected nucleosides and nucleotides for oligonucleotide synthesis and prodrug development.
• Agrochemical Research: Serves as a precursor in the development of new plant growth regulators or herbicides with purine scaffolds.
• Process Chemistry: Employed in scalable manufacturing processes where the trimethylsilyl groups provide solubility and reactivity advantages.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in heterocyclic chemistry and medicinal chemistry programs.
• Specialty Chemical Synthesis: Used to create functionalized purines for materials science applications, such as ligands for catalysts or organic electronic materials.

Basic Information

Product Name	1,7-Dihydro-2-(Dimethylamino)-6H-Purin-6-One Bis(Trimethylsilyl)
CAS No.	72088-18-7
Molecular Formula	C14H27N5OSi2
Molecular Weight	337.57 g/mol
Synonyms	2-(Dimethylamino)-1,7-dihydro-6H-purin-6-one bis(trimethylsilyl) ether; N,N-Dimethyl-2-(trimethylsilyloxy)-9-(trimethylsilyl)purin-6-amine; 2-(Dimethylamino)hypoxanthine bis(trimethylsilyl) derivative; 2-Dimethylaminopurine-6-one bis(TMS); TMS-protected 2-dimethylaminohypoxanthine; Bis-O-TMS-2-dimethylaminohypoxanthine; 72088-18-7; 2-(Dimethylamino)purin-6-ol bis(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 1,7-Dihydro-2-(Dimethylamino)-6H-Purin-6-One Bis(Trimethylsilyl) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and process-scale applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. For customers with specific regulatory needs, we can discuss compliance with relevant ICH guidelines and support documentation for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.