Description

Fmoc-Tyr(Tbu)-Oh CAS NO 71989-38-3 is a protected derivative of the amino acid tyrosine, specifically designed for use in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers who require high-purity, sequence-specific building blocks to construct complex peptides and proteins. It is an essential raw material for pharmaceutical R&D, particularly in the development of therapeutic peptides, as well as for biochemical research and proteomics studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the sequential assembly of peptide chains on resin.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel therapeutic peptide candidates for various disease targets.
• Bioconjugation and Protein Engineering: Serves as a modified tyrosine residue for introducing specific functional groups or labels into biomolecules.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Industrial Biochemistry: Essential for basic research involving protein structure-function studies, enzyme substrates, and antibody fragments.
• Production of Custom Peptides: A fundamental reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering peptide synthesis services.

Basic Information

Product Name	Fmoc-Tyr(Tbu)-Oh
CAS No.	71989-38-3
Molecular Formula	C28H29NO5
Molecular Weight	459.54 g/mol
Synonyms	Fmoc-O-tert-butyl-L-tyrosine; N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine; Fmoc-Tyr(O-t-Bu)-OH; Fmoc-L-Tyrosine(O-t-butyl); N-α-Fmoc-O-tert-butyl-L-tyrosine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(tert-butoxy)phenyl]propanoic acid; Fmoc-Tyr(Tbu)-OH; Fmoc-Tyr(OBut)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(Tbu)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research and cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.