Description

Fmoc-Pro-Oh CAS NO 71989-31-6 is a high-purity, protected amino acid derivative, specifically N-(9-Fluorenylmethoxycarbonyl)-L-proline, essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and sequential assembly of complex peptides and proteins in research and pharmaceutical development. It is primarily required by biotechnology firms, pharmaceutical R&D laboratories, and academic institutions engaged in peptide chemistry, drug discovery, and proteomics research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the Fmoc-strategy of peptide chain elongation, particularly for introducing proline residues.
• Pharmaceutical Intermediate: Used in the research and development of therapeutic peptides, including hormone analogs, antiviral agents, and enzyme inhibitors.
• Bioconjugation: Acts as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers in diagnostic and biotech applications.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Academic & Industrial Research: A standard reagent for studying protein structure-function relationships, peptide folding, and molecular recognition processes.
• Production of Custom Peptides: Essential for contract research organizations (CROs) and manufacturers specializing in bespoke peptide synthesis for clients.

Basic Information

Item	Detail
Product Name	Fmoc-Pro-Oh
CAS No.	71989-31-6
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.37 g/mol
Synonyms	N-(9-Fluorenylmethoxycarbonyl)-L-proline; Fmoc-L-proline; Fmoc-Pro-OH; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carboxylic acid; N-α-Fmoc-L-proline; 9-Fluorenylmethyloxycarbonyl-L-proline; Fmoc-Proline; N-Fmoc-L-proline
EINECS	Contact for details

Quality Control

Our Fmoc-Pro-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-58.0° to -62.0° (c=1, DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.