Description

L-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 4-Nitrophenyl Ester is a specialized, activated amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). This compound, identified by CAS number 71989-30-5, is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with precise sequence control. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated Fmoc-protected phenylalanine derivative, it serves as a crucial monomer for the sequential, automated assembly of peptide chains on resin supports.
• Pharmaceutical Research & Development: Used in the synthesis of novel peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation: Acts as a reagent for introducing phenylalanine residues into proteins, antibodies, or other biomolecules under controlled conditions.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Academic & Biochemical Research: Essential for fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.
• Production of Custom Peptides: Used by CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for the reliable and scalable production of bespoke peptides.

Basic Information

Product Name	L-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 4-Nitrophenyl Ester
CAS No.	71989-30-5
Molecular Formula	C31H24N2O6
Molecular Weight	520.54 g/mol
Synonyms	Fmoc-Phe-ONp; Fmoc-L-Phenylalanine 4-Nitrophenyl Ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine 4-nitrophenyl ester; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid 4-nitrophenyl ester; Fmoc-Phenylalanine p-nitrophenyl ester; Fmoc-Phe-OPnp; Fmoc-Phenylalanine-ONp; Fmoc-Phe-ONp ester
EINECS	Contact for details

Quality Control

Our L-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 4-Nitrophenyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and moisture content analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.