Description

Fmoc-Lys(Boc)-Oh CAS NO 71989-26-9 is a protected amino acid derivative, specifically an N-α-Fmoc and N-ε-Boc protected L-lysine, serving as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled, sequential assembly of complex peptides by providing orthogonal protection for the lysine side chain, which is essential for synthesizing peptides containing multiple lysine residues or requiring specific side-chain modifications. This high-purity reagent is indispensable for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on creating novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the Fmoc-strategy, enabling the incorporation of protected lysine into peptide chains.
• Pharmaceutical Intermediate: For the research and production of peptide-based active pharmaceutical ingredients (APIs), including hormones, antibiotics, and antiviral agents.
• Bioconjugation and Labeling: The free carboxylic acid and protected amine groups allow for selective conjugation to other molecules, proteins, or solid supports.
• Combinatorial Chemistry: Used in libraries for drug discovery to create diverse arrays of peptide compounds for high-throughput screening.
• Academic & Biochemical Research: A fundamental reagent for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Production of Custom Peptides: Essential for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering peptide synthesis services.

Basic Information

Product Name	Fmoc-Lys(Boc)-Oh
CAS No.	71989-26-9
Molecular Formula	C27H34N2O6
Molecular Weight	482.57 g/mol
Synonyms	Fmoc-Lys(Boc)-OH; N-α-Fmoc-N-ε-Boc-L-lysine; Fmoc-Lys(Boc)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)hexanoic acid; Fmoc-Lys(Boc)-OH; Boc-Lys(Fmoc)-OH; Nε-Boc-Nα-Fmoc-L-lysine; Fmoc-Lys(Boc)-OH Peptide Synthesis Grade
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Boc)-Oh is manufactured under strict quality systems to ensure consistency and reliability for critical research and production applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity, optical rotation verification, and identity confirmation (IR, NMR). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all relevant specifications to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	-12.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.