Description

Nalpha-Fmoc-L-Glutamine CAS NO 71989-20-3 is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its core value lies in providing a reactive glutamine side chain while the Fmoc group offers orthogonal protection, enabling the precise and efficient construction of complex peptides. This high-purity building block is critically needed by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories developing therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated, stepwise assembly of peptide chains.
• Pharmaceutical Research: Key intermediate in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to incorporate glutamine residues into peptides designed for labeling or coupling to other biomolecules.
• Combinatorial Chemistry: Essential building block for creating diverse peptide libraries used in high-throughput screening for drug discovery.
• Biochemical Research: Synthesis of substrates, inhibitors, and standards for enzymatic studies and assay development.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Nalpha-Fmoc-L-Glutamine
CAS No.	71989-20-3
Molecular Formula	C₂₀H₂₀N₂O₅
Molecular Weight	368.38 g/mol
Synonyms	Fmoc-Gln-OH; Fmoc-L-Glutamine; N-(9-Fluorenylmethoxycarbonyl)-L-glutamine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-5-amino-5-oxopentanoic acid; N-α-Fmoc-L-glutamine; Fmoc-Glutamine; N-Fmoc-L-glutamine; L-Glutamine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Nalpha-Fmoc-L-Glutamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-14.0° to -16.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.