Description

Fmoc-Asn-Onp CAS NO 71989-17-8 is a protected amino acid derivative, specifically the p-nitrophenyl ester of N-α-Fmoc-L-asparagine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of asparagine into peptide chains. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient coupling of Fmoc-protected asparagine during automated or manual peptide assembly.
• Pharmaceutical Research: A key intermediate in the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Used to introduce asparagine residues or peptide segments onto other biomolecules, surfaces, or polymers for creating targeted conjugates.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Proteomics & Biochemical Research: Synthesis of defined peptide sequences used as substrates, standards, or probes in enzymatic studies and analytical assays.
• Custom Peptide Service Providers: A staple reagent for CROs and manufacturers offering bespoke peptide synthesis services to the global research community.

Basic Information

Product Name	Fmoc-Asn-Onp
CAS No.	71989-17-8
Molecular Formula	C25H21N3O7
Molecular Weight	475.45 g/mol
Synonyms	Fmoc-L-asparagine p-nitrophenyl ester; N-α-Fmoc-L-asparagine 4-nitrophenyl ester; (9H-Fluoren-9-ylmethoxy)carbonyl-L-asparagine 4-nitrophenyl ester; Fmoc-Asn-ONp; Fmoc-Asparagine-ONp; Fmoc-Asn(ONp)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-asparagine p-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Asn-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with the stringent requirements of pharmaceutical R&D and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.