Description

6-Ethynyluracil is a specialized pyrimidine derivative featuring an ethynyl substituent, which imparts unique reactivity and binding properties. This compound is a critical building block and research chemical in the development of novel pharmaceuticals and diagnostic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleoside chemistry, enzyme inhibition studies, and the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel nucleoside analogs and prodrugs for antiviral and anticancer applications.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidylate synthase or other uracil-processing enzymes.
• Probe Development: The ethynyl group enables click chemistry applications, facilitating the creation of fluorescent probes or affinity labels for target identification.
• Organic Synthesis: Acts as a versatile building block for constructing more complex heterocyclic systems and modified nucleobases.
• Material Science: Investigated for potential use in the development of advanced organic electronic materials due to its conjugated structure.

Basic Information

Product Name	6-Ethynyluracil
CAS No.	71937-27-4
Molecular Formula	C6H4N2O2
Molecular Weight	136.11 g/mol
Synonyms	6-Ethynyl-2,4(1H,3H)-pyrimidinedione; 6-Ethynyl-1H-pyrimidine-2,4-dione; 2,4-Dihydroxy-6-ethynylpyrimidine; Uracil, 6-ethynyl-; 6-Ethynyluracil
EINECS	Contact for details

Quality Control

Our 6-Ethynyluracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.