Description

H-D-Phe-Nh2 Hcl is a high-purity, non-natural amino acid derivative, specifically the hydrochloride salt of D-Phenylalanine amide. This chiral building block is essential for the synthesis of complex peptides and active pharmaceutical ingredients (APIs) where precise stereochemistry is critical. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the D-phenylalanine residue with an amidated C-terminus.
• Proteomics & Biochemical Research: Serves as a standard or reagent in metabolic pathway studies and enzyme-substrate interaction research.
• Asymmetric Catalysis: Employed as a ligand or precursor in the development of chiral catalysts for asymmetric synthesis.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC or LC-MS method development.

Basic Information

Product Name	H-D-Phe-Nh2 Hcl
CAS No.	71666-94-9
Molecular Formula	C9H13N2O·HCl
Molecular Weight	200.67 g/mol (Free base: 165.22 g/mol)
Synonyms	D-Phenylalanine amide hydrochloride; (R)-2-Amino-3-phenylpropanamide hydrochloride; H-D-Phe-NH2·HCl; D-Phe-NH2 HCl; D-α-Phenylalanine amide hydrochloride; (R)-Phenylalanine amide hydrochloride; D-Phenylalaninamide hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Phe-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.