Description

6'-n-Methylfortimicin B is a semi-synthetic derivative of the fortimicin class of aminoglycoside antibiotics. This compound is of significant interest in pharmaceutical research and development due to its potential for enhanced antibacterial activity and modified pharmacokinetic profiles compared to its parent molecules. It serves as a critical intermediate and reference standard for researchers in the fields of medicinal chemistry and antibiotic discovery. The target markets include global pharmaceutical R&D laboratories, academic institutions, and fine chemical suppliers specializing in advanced antibiotic intermediates.

Application

• Pharmaceutical Research Intermediate: Used as a key building block in the synthesis of novel aminoglycoside antibiotic candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in antibiotic analysis.
• Medicinal Chemistry Studies: Employed in structure-activity relationship (SAR) studies to understand and improve antibacterial efficacy and reduce toxicity.
• Microbiological Research: Utilized in in-vitro studies to evaluate spectrum of activity against resistant bacterial strains.
• Process Development: Acts as a benchmark in the scaling up and optimization of synthetic routes for related antibiotic compounds.

Basic Information

Product Name	6'-n-Methylfortimicin B
CAS No.	71657-32-4
Molecular Formula	C20H41N5O8
Molecular Weight	479.57 g/mol
Synonyms	6'-N-Methylfortimicin B; Fortimicin B, 6'-N-methyl-; Antibiotic KA-6606 IX; (2R,3S,4S,5R,6R)-5-Amino-2-[[(2S,3R,4S,5S,6R)-4,5-diamino-6-[(1R)-1-(methylamino)ethyl]-2-oxanyl]oxy]-6-(aminomethyl)-3,4-dihydroxy-tetrahydro-2H-pyran-2-carboxylic acid; 6'-Methylfortimicin B; 6'-N-Methylfortimicin B sulfate (salt); U-67978
EINECS	Contact for details

Quality Control

Our 6'-n-Methylfortimicin B is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and stringent tests for residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with standards expected for pharmaceutical research materials, ensuring reliability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.