Description

3-Hydroxyaspartic Acid is a non-proteinogenic amino acid derivative of aspartic acid, featuring an additional hydroxyl group on the β-carbon. This unique structural modification makes it a valuable chiral building block and intermediate in organic synthesis and biochemical research. It is primarily utilized by the pharmaceutical, biotechnology, and fine chemical industries for applications ranging from peptide synthesis to the development of enzyme inhibitors and metabolic pathway studies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, especially for aspartate aminotransferase and other enzymes involved in amino acid metabolism.
• Peptide Modification: Incorporated into synthetic peptides to introduce hydroxyl functionality, altering solubility, stability, and biological activity.
• Fine Chemical Synthesis: Acts as a precursor for the production of more complex organic molecules, chelating agents, and specialty chemicals.
• Metabolite Standard: Employed as a reference standard in analytical chemistry for mass spectrometry (MS) and high-performance liquid chromatography (HPLC) in metabolomics and clinical diagnostics.

Basic Information

Product Name	3-Hydroxyaspartic Acid
CAS No.	71653-06-0
Molecular Formula	C4H7NO5
Molecular Weight	149.10 g/mol
Synonyms	β-Hydroxyaspartic Acid; (2R,3S)-3-Hydroxyaspartic Acid; L-threo-3-Hydroxyaspartic Acid; HOA; 3-Hydroxy-L-aspartic Acid; 2-Amino-3-hydroxybutanedioic Acid; 3-Hydroxyaspartate
EINECS	Contact for details

Quality Control

Our 3-Hydroxyaspartic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, enantiomeric purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (L-threo)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.