Description

Parathyroid Hormone (7-34) Amide, Tyr(34)- CAS NO 71539-01-0 is a bioactive peptide fragment derived from the parathyroid hormone, specifically the 7-34 sequence with an amide group and a tyrosine residue at position 34. This compound is a critical research tool for studying calcium and phosphate metabolism, bone biology, and the structure-activity relationships of PTH. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies involved in endocrinology, osteoporosis research, and peptide-based drug discovery.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of parathyroid hormone receptor (PTH1R) binding, activation, and downstream signaling pathways.
• Drug Discovery & Development: Serves as a key intermediate or analog in the design and screening of novel therapeutics targeting bone disorders such as osteoporosis and hyperparathyroidism.
• Endocrinology Studies: Essential for in vitro and in vivo experiments investigating the regulation of calcium homeostasis and bone remodeling processes.
• Peptide Chemistry: Acts as a substrate for studying peptide stability, modification techniques, and structure-activity relationship (SAR) analysis.
• Diagnostic Development: Potential use in the development of immunoassays and diagnostic kits for measuring PTH-related activity.
• Cell Culture & Biochemistry: Employed in cell-based assays to stimulate cAMP production and other second messenger systems in osteoblast and kidney cell lines.

Basic Information

Product Name	Parathyroid Hormone (7-34) Amide, Tyr(34)- CAS NO 71539-01-0
CAS No.	71539-01-0
Molecular Formula	C₁₄₀H₂₂₀N₄₂O₄₀
Molecular Weight	~3149.6 g/mol
Synonyms	PTH (7-34) amide, Tyr(34)-; Parathyroid Hormone Fragment 7-34 amide; [Tyr34]PTH(7-34)NH2; hPTH(7-34)-NH2, Tyr34; PTHrP-related peptide; Parathyroid hormone-like peptide (7-34) amide; Calcium metabolism research peptide
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (7-34) Amide, Tyr(34)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation, to ensure it meets high-grade research specifications. Certificates of Analysis (COA) with detailed chromatographic data and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Biological Activity	Assayed by cAMP stimulation in cell-based assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.